Galleria mellonella as a Model System To Study Cryptococcus neoformans Pathogenesis

Galleria mellonella as a model system to study Cryptococcus neoformans pathogenesis.

Evaluation of Cryptococcus neoformans virulence in a number of nonmammalian hosts suggests that C. neoformans is a nonspecific pathogen. We used the killing of Galleria mellonella (the greater wax moth) caterpillar by C. neoformans to develop an invertebrate host model system that can be used to study cryptococcal virulence, host immune responses to infection, and the effects of antifungal comp...

Galleria mellonella as a model system to study Acinetobacter baumannii 1 pathogenesis and therapeutics 2 3

Galleria mellonella as a model system to study Acinetobacter baumannii pathogenesis and therapeutics.

Nonmammalian model systems of infection such as Galleria mellonella (caterpillars of the greater wax moth) have significant logistical and ethical advantages over mammalian models. In this study, we utilize G. mellonella caterpillars to study host-pathogen interactions with the gram-negative organism Acinetobacter baumannii and determine the utility of this infection model to study antibacteria...

The wax moth Galleria mellonella as a novel model system to study Enteroaggregative Escherichia coli pathogenesis

Enteroaggregative Escherichia coli (EAEC) comprise of a large, diverse group of diarrheagenic E. coli defined by their characteristically ‘stacked brick’ pattern on HEp-2 cells. EAEC was first associated with children’s diarrhea in developing countries but studies have since shown that EAEC is the cause of both acute and persistent diarrhea in all ages worldwide. Moreover, EAEC has been implica...

The insect Galleria mellonella as a powerful infection model to investigate bacterial pathogenesis.

The study of bacterial virulence often requires a suitable animal model. Mammalian models of infection are costly and may raise ethical issues. The use of insects as infection models provides a valuable alternative. Compared to other non-vertebrate model hosts such as nematodes, insects have a relatively advanced system of antimicrobial defenses and are thus more likely to produce information r...